This syndrome is classically due to germline mutations in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2. Lynch syndrome, originally described in 1913 and previously known as hereditary nonpolyposis colorectal carcinoma syndrome, is the most common hereditary cancer syndrome. Visit for more related articles at Journal of Gastrointestinal & Digestive System This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received date: NovemAccepted date: NovemPublished date: November 26, 2013Ĭitation: Huber AR, Whitney-Miller DOCL, Jennifer, Findeis-Hosey J (2013) An Update on the Pathogenesis of Lynch Syndrome: Recently Described Novel Molecular Mechanisms. Surgical Pathology Unit 601 Elmwood Avenue Surgical Pathology Unit, University of Rochester Medical Center, USA *Corresponding Author: Aaron Ryan Huber An Update on the Pathogenesis of Lynch Syndrome: Recently Described Novel Molecular Mechanisms Aaron R.
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